Bladder Cancer Surgery

Journal of Endourology , Vol. 0, No. 0. (Source: Journal of Endourology) Source: MedWorm: Bladder Cancer

MDR1 and ERCC1 expression predict outcome of patients with locally advanced … UroToday The role of adjuvant chemotherapy in patients with locally advanced bladder cancer still remains to be defined. We hypothesized that assessing the gene …

Source: bladder cancer – Google News

CONCLUSIONS: Having biological materials characterized and available along with the clinical patient information provides an integrated portrait of the patients and their diseases facilitating advances in molecular biology. It also promotes the development of translational research improving methods of diagnosis and cancer treatment. (Source: International Braz J Urol) Source: MedWorm: Bladder Cancer

Prognostic value of lymphovascular invasion in bladder cancer in patients … UroToday Bladder cancer is the fourth most frequently diagnosed cancer among males and the eleventh among females. At present, radical cystectomy is considered the …

Source: bladder cancer – Google News

(Source: BJU International) Source: MedWorm: Bladder Cancer

Study Type – Prognosis (inception cohort)
Level of Evidence 1b (Source: BJU International)

Source: MedWorm: Bladder Cancer

CONCLUSIONS: High MDR1 and ERCC1 gene expressions are associated with inferior outcome after cisplatin-based adjuvant chemotherapy for locally advanced bladder cancer. Prospective studies are warranted to define a role for MDR1 and ERCC1 analysis in individualizing multimodality treatment in locally advanced bladder cancer.
PMID: 20689757 [PubMed - in process] (Source: Neoplasia) Source: MedWorm: Bladder Cancer

CONCLUSION: Due to rapid tumor progression and toxicity at this dosage and schedule in a multicenter setting, it was not feasible to deliver a prolonged regimen. However, a high response rate of approximately 40% makes GP a promising second-line treatment option for patients with metastatic UC.
PMID: 20682548 [PubMed - as supplied by publisher] (Source: Ann Oncol) Source: MedWorm: Bladder Cancer

Authors: Ha MS, Chang IH
The aim of this study was to determine the impact that age and comorbidity status have on both overall and bladder cancer-specific survival of bladder cancer patients. We obtained medical information pertaining to a population of 528 patients with newly diagnosed bladder cancer from Chung-Ang University Hospital cancer registry. The Adult Comorbidity Evaluation-27 (ACE-27) test, which has been previously validated in adult cancer patients, was used to assess comorbidity. We evaluated differences in the demographic and clinical characteristics of included patients, as well as differences in the treatments they received after categorizing them by age. The median age at the time of bladder cancer diagnosis of the entire cohort was 63 years, and the median follow-u… Source: MedWorm: Bladder Cancer

Source: Clinical Cancer Research, Reuters Health
Area: News
According to the findings of a retrospective analysis, the use of adjuvant chemotherapy (AC) after radical cystectomy is of benefit to patients with high-risk bladder cancer.
 
The authors note that there is evidence to suggest a survival advantage with AC following radical cystectomy; however limited conclusions can be drawn from this due to methodological issues and small sample sizes.  Because of this the routine use of AC has not gained widespread acceptance.  They decided to research this area further by conducting a multicentre observational study.
 
Data from patients with a diagnosis of transitional cell carcinoma of the bladder treated with radical cystectomy and lymphadenectomy at one of 11 i… Source: MedWorm: Bladder Cancer