Imatinib mesylate has revolutionized the treatment of chronic myeloid leukemia (CML), providing an excellent disease control and showing a satisfactory tolerance . However, due to a relatively short period of about 10 years of the clinical experience with this drug, a possible contribution of imatinib to the development of secondary neoplasms has not been definitively determined. Recently, Frustaci et al. reported on the occurrence of colon adenocarcinoma in 2 out of 150 CML late chronic phase patients treated with imatinib. In 2005, Roy et al. documented an unexpected occurrence of second malignancies, particularly those originating from the uroepithelial tissue in 6/189 CML patients treated with interferon-α (IFN-α) followed by imatinib. This series included 3 cases of a prostate cance…
Christopher Pascale, a patient of Carol Salem, MD, medical director of the Scripps Minimally Invasive Robotic Surgery Program, discusses his experience with robotic surgery to remove his bladder and prostate for the treatment of bladder cancer.
Patient William Hurley discusses his experience with Carol Salem, MD, and the Scripps Minimally Invasive Robotic Surgery Program after having robot-assisted surgery to remove his bladder and prostate as a part of his treatment for bladder cancer.
We describe here the case of a 50-year-old man
with advanced bladder cancer who suddenly experienced diminished spontaneity and speech, and finally became semicomatose.
Two months previously, he had received gemcitabine and cisplatin chemotherapy. Computed tomography and magnetic resonance
imaging revealed symmetrical edema of the posterior occipital lobe and thalamus. Based on these findings, we made a diagnosis
of RPLS and treated him with supportive measures. His mental status gradually improved in 2 weeks, although slight neurological
symptoms persisted. When the level of consciousness of a cancer patient worsens rapidly, this syndrome should be included
in the differential diagnosis and recognized at an early stage. Early supportive management and discontinuation of the cau…
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In this issue of The Jounal 3 articles examine the results of performing what has been considered by most urologists, up to this time, less than adequate procedures for testicular masses, ureteral tumors and bladder cancer. These articles have their individual limitations but provide evidence for reconsideration of the necessity of radical extirpative surgical procedures for these particular diseases. (Source: The Journal of Urology)
Source: MedWorm: Bladder Cancer
Certain foods are associated with an increased or a decreased risk of bladder cancer, and diet should
be a component of care for patients with the disease, according to an article published in the February issue of
Urology. (Source: Modern Medicine)
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We report a case of gefitinib-induced bilateral upper urinary tract bleeding in an 82-year-old woman administered the drug daily for advanced non-small cell adenocarcinoma of the lung (T4N3M0). Hematuria is an uncommon adverse effect of gefitinib, and in most cases, the bleeding site is unknown. On the 44th day of oral gefitinib administration, the patient noted asymptomatic macroscopic bloody urine. Cystoscopy revealed bleeding from the bilateral ureteric orifices without hemorrhagic inflammation of the bladder. One week later, she was admitted complaining of severe abdominal pain, and her condition was found to be complicated by liver damage and renal dysfunction. We stopped gefitinib administration and started hydration and diuresis. Renal function and urine output soon recovered, and a…
Source: MedWorm: Bladder Cancer
Conclusions:
Our findings would suggest that the BC disease course is determined by not only a patient’s age, but also by the molecular characteristics of a tumor. This young patient contained typical genetic changes found in tumors of older patients and implies a clinical disease course comparable to older patients. We demonstrate that FGFR3 mutation analysis on voided urine is a simple non-invasive method and could serve as a feasible follow-up approach for this young patient presenting with an FGFR3 mutant tumor. (Source: BioMed Central)
Source: MedWorm: Bladder Cancer
