β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation
Oncogene advance online publication, September 6, 2010. doi:10.1038/onc.2010.399
Authors: I Ahmad, J P Morton, L B Singh, S M Radulescu, R A Ridgway, S Patel, J Woodgett, D J Winton, M M Taketo, X-R Wu, H Y Leung
& O J Sansom (Source: Oncogene)
Source: MedWorm: Bladder Cancer
Despite epidemiologic data supporting a significant genetic contribution to the cause of genitourinary malignancies, their diagnosis rarely results in clinical genetics referral and the heritability of prostate, bladder, kidney, and testicular cancer remains poorly understood. Little of this inheritance has been explained by rare, high-penetrance predisposition syndromes and, although rare genetic variation may explain some of the remaining familial predisposition, recent genome-wide association studies support an important causal role for more common genomic variation and other structural variants. Susceptibility loci associated with risk of prostate, bladder, and testicular cancer have been identified that may improve our understanding of the cause and natural history of these malignanci…
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Source: MedWorm: Bladder Cancer
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New Developments in Bladder Cancer Diagnosis
PR Web (press release) According to the American Cancer Society, approximately 70530 new cases of bladder cancer will be diagnosed this year, resulting in nearly 15000 deaths. … |
Source: bladder cancer – Google News
Journal of Endourology , Vol. 0, No. 0. (Source: Journal of Endourology) Source: MedWorm: Bladder Cancer
Conclusion
FDG-PET/CT has excellent sensitivity and specificity in the detection of metastatic bladder cancer and provides additional diagnostic information that enhances clinical management more than CT/MRI alone. FDG-PET/CT scans may provide better accuracy in clinical information for directing therapy. (Source: Journal of Clinical Oncology)
Source: MedWorm: Bladder Cancer
Authors: Azuma H, Inamoto T, Ibuki N, Ubai T, Kotake Y, Takahara K, Kiyama S, Nomi H, Uehara H, Komura K, Yamamoto K, Narumi Y, Katsuoka Y
We investigated the effect of balloon-occluded arterial infusion (BOAI) of anticancer agent (cisplatin/gemcitabine), used concomitantly with hemodialysis, which delivers an extremely high concentration of anticancer agent to the site of a tumor without systemic adverse effects, along with concurrent radiation (referred to as the OMC-regimen) in patients with advanced bladder cancer. One hundred and ninety-two patients were assigned to receive either the OMC-regimen (n=96) or total cystectomy (n=96). Patients in the OMC-regimen group who failed to achieve CR underwent cystectomy, or secondary BOAI with an increased amount of CDDP or gemcitabine (1600…
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Source: MedWorm: Bladder Cancer
 Eureka! Science News |
Selenium May Protect Against Bladder Cancer
WebMD They reviewed selenium levels taken from blood samples and toenail clippings and determined each patient's risk of developing bladder cancer. … Selenium Linked to Lower Bladder Cancer Risk Selenium Linked to Lower Bladder Cancer Risk Higher Selenium Level Linked to Lower Bladder Cancer Risk Meta-analysis shows … |
Source: bladder cancer – Google News
Authors: Oliva Encina J, Marco Valdenebro A, PelegràGabarró J, Rioja Sanz C
Cystoscopy is gold-standard method in non muscule invasive bladder cancer diagnosis. In the cistoscopic exploratión 30% of tumors could be overlooked: it is due to a flat forms, little size tumours or difficult visualization. Photodynamic diagnosis reduces overlooked tumours rate, and has improved diagnosis on flat forms, with the consequence of increasing lap time to recurrence and decreasing the number of iterative cistoscopy; nevertheless the false positive rate is high. In the last years developed new optical devices who try to improve alone or associated diagnostic sensibility in cistoscopy without reduction of specificity. Among new devices we must emphasize some like Narrow Band Imaging, Optica…
Source: MedWorm: Bladder Cancer
Increased selenium intake may decrease bladder cancer risk by 39 percent, according to a meta-analysis
published online Aug. 31 in Cancer Epidemiology, Biomarkers & Prevention. (Source: Modern Medicine)
Source: MedWorm: Bladder Cancer